Difference between Qualcomm QC 3.0 and Anker IQ?

Hello, I recently acquired a Powercore 20000 QC and was wondering about the true differences between each output port. Is it safe to hook up a non-QC device to the QC port? I know there’s “voltage boost” but which one supports that? Both ports? I only got this because my girlfriend has a phone that takes advantage of 12v charging or something like that. But I have an S5, which doesn’t.